Brian M. Alexander, M.D., M.P.H.

Brian M. Alexander, M.D, M.P.H.
Associate Professor of Radiation Oncology, Harvard Medical School
Disease Center Leader for Radiation Oncology, Center for Neuro-Oncology
Dana-Farber/Brigham and Women’s Cancer Center

Dr. Alexander is an associate professor of radiation oncology at Harvard Medical School and is the disease center leader for radiation oncology in the Center for Neuro-Oncology at the Dana-Farber/Brigham and Women’s Cancer Center. He serves as head of the Program for Regulatory Science at the Dana-Farber Cancer Institute and is deputy director of the Harvard/MIT Center for Regulatory Science.

Dr. Alexander received his B.A. from Kalamazoo College, his M.D. from the University of Michigan Medical School, and his M.P.H. from the Harvard School of Public Health. He completed his training in radiation oncology at the Harvard Radiation Oncology Program.

His research interests focus on innovations in clinical evidence generation to support the development of therapeutics, biomarkers and novel endpoints. During his residency, he published a book on the use of Bayesian approaches to clinical decision making, and his work applying such approaches to clinical trial designs was supported by a Burroughs-Wellcome Innovations in Regulatory Science Award.

He is currently the principal investigator and sponsor of INSIGhT, a multi-institutional genomic biomarker-based, Bayesian adaptively randomized platform trial for patients with glioblastoma. He also co-founded the Global Coalition for Adaptive Research to facilitate the construction of learning systems to accelerate development of new therapies and biomarkers, and serves as its president and chief executive officer. His research also includes evidence generation from patient-derived preclinical models and the statistical modeling and synthesis of therapeutic development data from multiple sources.

Previously, Dr. Alexander was a White House Fellow and special assistant to the Secretary of Veterans Affairs (VA). In that role, he helped prepare the VA for the transition of administrations, worked to develop a public reporting system for quality, and served as a health policy advisor to the Secretary. He organized the standup of the VA’s Coordinating Council on National Health Reform and directed the activities of its multi-team Health Reform Working Group. He was also a member of the Institute of Medicine’s Committee on the Governance and Financing of Graduate Medical Education.